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Significance of kinase activity in the dynamic invadosome

Foxall, E; Pipili, A; Jones, GE; Wells, CM; (2016) Significance of kinase activity in the dynamic invadosome. European Journal of Cell Biology , 95 (11) pp. 483-492. 10.1016/j.ejcb.2016.07.002. Green open access

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Abstract

Invadosomes are actin rich protrusive structures that facilitate invasive migration in multiple cell types. Comprised of invadopodia and podosomes, these highly dynamic structures adhere to and degrade the extracellular matrix, and are also thought to play a role in mechanosensing. Many extracellular signals have been implicated in invadosome stimulation, activating complex signalling cascades to drive the formation, activity and turnover of invadosomes. While the structural components of invadosomes have been well studied, the regulation of invadosome dynamics is still poorly understood. Protein kinases are essential to this regulation, affecting all stages of invadosome dynamics and allowing tight spatiotemporal control of their activity. Invadosome organisation and function have been linked to pathophysiological states such as cancer invasion and metastasis; therapeutic targeting of invadosome regulatory components is thus warranted. In this review, we discuss the involvement of kinase signalling in every stage of the invadosome life cycle and evaluate its significance.

Type: Article
Title: Significance of kinase activity in the dynamic invadosome
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ejcb.2016.07.002
Publisher version: https://doi.org/10.1016/j.ejcb.2016.07.002
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Cell Biology, Invadopodia, Podosomes, Kinases, Src, Tyrosine phosphorylation, Actin, CANCER-CELL INVASION, HUMAN BREAST-CANCER, WISKOTT-ALDRICH-SYNDROME, FOCAL ADHESION KINASE, EXTRACELLULAR-MATRIX DEGRADATION, NUCLEOTIDE EXCHANGE FACTOR, PROTEIN-TYROSINE KINASES, AORTIC ENDOTHELIAL-CELLS, SMOOTH-MUSCLE-CELLS, INVADOPODIA FORMATION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/10074218
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