Hobson, NJ;
Weng, X;
Siow, B;
Veiga, C;
Ashford, M;
Thanh, NT;
Schätzlein, AG;
(2019)
Clustering superparamagnetic iron oxide nanoparticles produces organ-targeted high-contrast magnetic resonance images.
Nanomedicine
, 14
(9)
pp. 1135-1152.
10.2217/nnm-2018-0370.
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Abstract
AIM: Superparamagnetic iron oxide nanoparticles (SPIONs) have been used as magnetic resonance imaging (MRI) contrast agents; however, a number of T2-weighted imaging SPIONs have been withdrawn due to their poor clinical contrast performance. Our aim was to significantly improve SPION T2-weighted MRI contrast by clustering SPIONs within novel chitosan amphiphiles. METHODS: Clustering SPIONs was achieved by encapsulation of hydrophobic-coated SPIONs with an amphiphilic chitosan polymer (GCPQ). RESULTS: Clustering increases the spin-spin (r2) to spin-lattice (r1) relaxation ratio (r2/r1) from 3.0 to 79.1, resulting in superior contrast. Intravenously administered clustered SPIONs accumulated only in the liver and spleen; with the reduction in T2 relaxation confined, in the liver, to the extravascular space, giving clear MRI images of the liver vasculature.
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