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Biological and predictive role of ERCC1 polymorphisms in cancer

Formica, V; Doldo, E; Antonetti, FR; Nardecchia, A; Ferroni, P; Riondino, S; Morelli, C; ... Roselli, M; + view all (2017) Biological and predictive role of ERCC1 polymorphisms in cancer. Critical Reviews in Oncology/Hematology , 111 pp. 133-143. 10.1016/j.critrevonc.2017.01.016. Green open access

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Abstract

Excision repair cross-complementation group 1 (ERCC1) is a key component in DNA repair mechanisms and may influence the tumor DNA-targeting effect of the chemotherapeutic agent oxaliplatin. Germline ERCC1 polymorphisms may alter the protein expression and published data on their predictive and prognostic value have so far been contradictory. In the present article we review available evidence on the clinical role and utility of ERCC1 polymorphisms and, in the absence of a ‘perfect’ trial, what we call the ‘sliding doors’ trial, we present the data of ERCC1 genotyping in our local patient population. We found a useful predictive value for oxaliplatin-induced risk of anemia.

Type: Article
Title: Biological and predictive role of ERCC1 polymorphisms in cancer
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.critrevonc.2017.01.016
Publisher version: https://doi.org/10.1016/j.critrevonc.2017.01.016
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: ERCC1, Oxaliplatin, Single nucleotide polymorphisms, Colorectal cancer
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/10073405
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