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Manufacturing chimeric antigen receptor T cells: issues and challenges

Roddie, C; O'Reilly, M; Dias Alves Pinto, J; Vispute, K; Lowdell, M; (2019) Manufacturing chimeric antigen receptor T cells: issues and challenges. Cytotherapy , 21 (3) pp. 327-340. 10.1016/j.jcyt.2018.11.009.

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Abstract

Clinical trials of adoptively transferred CD19 chimeric antigen receptor (CAR) T cells have delivered unprecedented responses in patients with relapsed refractory B-cell malignancy. These results have prompted Food and Drug Administration (FDA) approval of two CAR T-cell products in this high-risk patient population. The widening range of indications for CAR T-cell therapy and increasing patient numbers present a significant logistical challenge to manufacturers aiming for reproducible delivery systems for high-quality clinical CAR T-cell products. This review discusses current and novel CAR T-cell processing methodologies and the quality control systems needed to meet the increasing clinical demand for these exciting new therapies.

Type: Article
Title: Manufacturing chimeric antigen receptor T cells: issues and challenges
Location: England
DOI: 10.1016/j.jcyt.2018.11.009
Publisher version: http://doi.org/10.1016/j.jcyt.2018.11.009
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: CliniMACS Prodigy, chimeric antigen receptor T cells, immunotherapy, lentiviral vectors
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/10072324
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