UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

microRNA in Cardiovascular Aging and Age-Related Cardiovascular Diseases

de Lucia, C; Komici, K; Borghetti, G; Femminella, GD; Bencivenga, L; Cannavo, A; Corbi, G; ... Rengo, G; + view all (2017) microRNA in Cardiovascular Aging and Age-Related Cardiovascular Diseases. Frontiers in Medicine , 4 , Article 74. 10.3389/fmed.2017.00074. Green open access

[img]
Preview
Text
Femminella_microRNA in Cardiovascular Aging and Age-Related Cardiovascular Diseases_VoR.pdf - ["content_typename_Published version" not defined]

Download (529kB) | Preview

Abstract

Over the last decades, life expectancy has significantly increased although several chronic diseases persist in the population, with aging as the leading risk factor. Despite improvements in diagnosis and treatment, many elderlies suffer from cardiovascular problems that are much more frequent in an older, more fragile organism. In the long term, age-related cardiovascular diseases (CVDs) contribute to the decline of quality of life and ability to perform normal activities of daily living. microRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at the posttranscriptional level in both physiological and pathological conditions. In this review, we will focus on the role of miRNAs in aging and age-related CVDs as heart failure, hypertension, atherosclerosis, atrial fibrillation, and diabetes mellitus. miRNAs are key regulators of complex biological mechanisms, representing an exciting potential therapeutic target in CVDs. Moreover, one major challenge in geriatric medicine is to find reliable biomarkers for diagnosis, prognosis, and prediction of the response to specific drugs. miRNAs represent a very promising tool due to their stability in the circulation and unique signature in CVDs. However, further studies are needed to investigate their translational potential in the real clinical practice.

Type: Article
Title: microRNA in Cardiovascular Aging and Age-Related Cardiovascular Diseases
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fmed.2017.00074
Publisher version: http://doi.org/10.3389/fmed.2017.00074
Language: English
Additional information: © 2017 de Lucia, Komici, Borghetti, Femminella, Bencivenga, Cannavo, Corbi, Ferrara, Houser, Koch and Rengo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
Keywords: microRNA, aging, cardiovascular diseases, heart failure, atherosclerosis, hypertension, diabetes, atrial fibrillation
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
URI: http://discovery.ucl.ac.uk/id/eprint/10072007
Downloads since deposit
26Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item