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Compulsivity and impulsivity traits linked to attenuated developmental fronto-striatal myelination trajectories

Ziegler, G; Hauser, TU; Moutoussis, M; Bullmore, ET; Goodyer, IM; Fonagy, P; Jones, PB; ... Dolan, RJ; + view all (2019) Compulsivity and impulsivity traits linked to attenuated developmental fronto-striatal myelination trajectories. Nature Neuroscience (In press).

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Ziegler et al Nat Neurosci March 2019.pdf - ["content_typename_Accepted version" not defined]
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Abstract

The transition from adolescence into adulthood is a period when ongoing brain development coincides with a substantially increased risk of psychiatric disorders. The developmental brain changes accounting for this emergent psychiatric symptomatology remain obscure. Capitalising on a unique longitudinal dataset that includes in-vivo myelin-sensitive magnetization transfer (MT) MRI, we show that this developmental period is characterised by brain-wide growth in MT, within both gray matter and adjacent juxta-cortical white matter. In this healthy population the expression of common developmental traits, namely compulsivity and impulsivity, is tied to a reduced growth of these MT trajectories in fronto-striatal regions. This reduction is most marked in dorsomedial and dorsolateral prefrontal regions for compulsivity, and in lateral and medial prefrontal regions for impulsivity. The findings highlight that psychiatric traits of compulsivity and impulsivity are linked to regionally specific reduction in myelin-related growth in late adolescent brain development.

Type: Article
Title: Compulsivity and impulsivity traits linked to attenuated developmental fronto-striatal myelination trajectories
Publisher version: https://www.nature.com/neuro/
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: http://discovery.ucl.ac.uk/id/eprint/10071075
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