UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Apathy Associated With Impaired Recognition of Happy Facial Expressions in Huntington's Disease

Osborne-Crowley, K; Andrews, SC; Labuschagne, I; Nair, A; Scahill, R; Craufurd, D; Tabrizi, SJ; ... TRACK-HD Investigators, .; + view all (2019) Apathy Associated With Impaired Recognition of Happy Facial Expressions in Huntington's Disease. Journal of the International Neuropsychological Society , 25 (5) pp. 453-461. 10.1017/S1355617718001224. Green open access

[thumbnail of Osborne-Crowley_Apathy.pdf]
Preview
Text
Osborne-Crowley_Apathy.pdf - Accepted Version

Download (262kB) | Preview

Abstract

OBJECTIVES: Previous research has demonstrated an association between emotion recognition and apathy in several neurological conditions involving fronto-striatal pathology, including Parkinson's disease and brain injury. In line with these findings, we aimed to determine whether apathetic participants with early Huntington's disease (HD) were more impaired on an emotion recognition task compared to non-apathetic participants and healthy controls. METHODS: We included 43 participants from the TRACK-HD study who reported apathy on the Problem Behaviours Assessment - short version (PBA-S), 67 participants who reported no apathy, and 107 controls matched for age, sex, and level of education. During their baseline TRACK-HD visit, participants completed a battery of cognitive and psychological tests including an emotion recognition task, the Hospital Depression and Anxiety Scale (HADS) and were assessed on the PBA-S. RESULTS: Compared to the non-apathetic group and the control group, the apathetic group were impaired on the recognition of happy facial expressions, after controlling for depression symptomology on the HADS and general disease progression (Unified Huntington's Disease Rating Scale total motor score). This was despite no difference between the apathetic and non-apathetic group on overall cognitive functioning assessed by a cognitive composite score. CONCLUSIONS: Impairment of the recognition of happy expressions may be part of the clinical picture of apathy in HD. While shared reliance on frontostriatal pathways may broadly explain associations between emotion recognition and apathy found across several patient groups, further work is needed to determine what relationships exist between recognition of specific emotions, distinct subtypes of apathy and underlying neuropathology. (JINS, 2019, 00, 1-9).

Type: Article
Title: Apathy Associated With Impaired Recognition of Happy Facial Expressions in Huntington's Disease
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1017/S1355617718001224
Publisher version: https://doi.org/10.1017/S1355617718001224
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Apathy, Cognition, Cognition disorders, Emotion, Huntington’s disease, Social behavior
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10069945
Downloads since deposit
88Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item