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Update on fluid biomarkers for concussion

Zetterberg, H; Morris, HR; Hardy, J; Blennow, K; (2016) Update on fluid biomarkers for concussion. Concussion , 1 (3) , Article CNC12. 10.2217/cnc-2015-0002. Green open access

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Abstract

Concussions are difficult to diagnose and symptoms may not appear immediately. As an accurate initial diagnosis has profound implications for the clinical management, there is an unmet need for better diagnostic tools. Fluid biomarkers for CNS injury may represent such tools. These markers are often proteins, peptides or other molecules with selective or high expression in the brain, which can be measured in the cerebrospinal fluid or blood as they leak out or get secreted into the biofluid in response to the injury. Here, we review the literature on fluid markers of neuronal, axonal and astroglial injury and response mechanisms to diagnose CNS injury upon head impact and to determine when the injurious process has resolved.

Type: Article
Title: Update on fluid biomarkers for concussion
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.2217/cnc-2015-0002
Publisher version: https://doi.org/10.2217/cnc-2015-0002
Language: English
Additional information: © Henrik Zetterberg 2019. This work is licensed under the Creative Commons Attribution 4.0 License. To view a copy of this license, visit (http://creativecommons.org/licenses/by/4.0/).
Keywords: biomarker, blood, cerebrospinal fluid, concussion, plasma
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10068950
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