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Main and interactive effects of inflammation and perceived neighbourhood cohesion on psychological distress: Results from a population-based study in the UK

Papachristou, E; Flouri, E; Kokosi, T; Francesconi, M; (2019) Main and interactive effects of inflammation and perceived neighbourhood cohesion on psychological distress: Results from a population-based study in the UK. Quality of Life Research 10.1007/s11136-019-02143-7. (In press). Green open access

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Abstract

PURPOSE: Low neighbourhood cohesion and increased levels of inflammation are independent predictors of psychological distress. In this study we explored if they also interact to predict it. METHODS: Our sample was 9,393 adult participants of the UK Household Longitudinal Study (UKHLS), a large longitudinal household panel study in the UK. Inflammation was measured using C-reactive protein levels. Perceived neighbourhood cohesion was measured using a 13-item questionnaire. Psychological distress was measured with the General Health Questionnaire-12. RESULTS: Perceived neighbourhood cohesion and inflammation retained their significant main effects on psychological distress even after adjustment for confounders (age, gender, ethnicity, partner status, education, smoking status, obesity and urbanicity). The effect of neighbourhood cohesion was larger. However, we did not find evidence for an interactive association between the two. CONCLUSIONS: Perceived neighbourhood cohesion was inversely related to psychological distress, over and above other important person- and neighbourhood-level characteristics. Inflammation was also associated with psychological distress, albeit less strongly. If these associations are causal, they suggest that promoting neighbourhood cohesion can alleviate some of the burden associated with psychological distress.

Type: Article
Title: Main and interactive effects of inflammation and perceived neighbourhood cohesion on psychological distress: Results from a population-based study in the UK
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s11136-019-02143-7
Publisher version: https://www.springer.com/medicine/journal/11136
Language: English
Additional information: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativeco mmons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: CRP, inflammation, neighborhood cohesion, psychological distress, Understanding Society
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Education
UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education
UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education > IOE - Psychology and Human Development
URI: http://discovery.ucl.ac.uk/id/eprint/10068626
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