Manoharan, A;
Rayner, PJ;
Fekete, M;
Iali, W;
Norcott, P;
Perry, VH;
Duckett, SB;
(2019)
Catalyst‐Substrate Effects on Biocompatible SABRE Hyperpolarization.
ChemPhysChem
, 20
(2)
pp. 285-294.
10.1002/cphc.201800915.
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Abstract
The hyperpolarization technique, Signal Amplification by Reversible Exchange (SABRE), has the potential to improve clinical diagnosis by making molecular magnetic resonance imaging in vivo a reality. Essential to this goal is the ability to produce a biocompatible bolus for administration. We seek here to determine how the identity of the catalyst and substrate affects the cytotoxicity by in vitro study, in addition to reporting how the use of biocompatible solvent mixtures influence the polarization transfer efficiency. By illustrating this across five catalysts and 8 substrates, we are able to identify routes to produce a bolus with minimal cytotoxic effects.
| Type: | Article |
|---|---|
| Title: | Catalyst‐Substrate Effects on Biocompatible SABRE Hyperpolarization |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/cphc.201800915 |
| Publisher version: | https://doi.org/10.1002/cphc.201800915 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | biocompatibility, biomolecules, cytotoxicity, hyperpolarization, SABRE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UK Dementia Research Institute HQ |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10068380 |
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