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Annotation of gene product function from high-throughput studies using the Gene Ontology

Attrill, H; Gaudet, P; Huntley, RP; Lovering, RC; Engel, SR; Poux, S; Van Auken, KM; ... Gene Ontology Consortium, ; + view all (2019) Annotation of gene product function from high-throughput studies using the Gene Ontology. Database , 2019 , Article baz007. 10.1093/database/baz007. (In press). Green open access

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Abstract

High-throughput studies constitute an essential and valued source of information for researchers. However, high-throughput experimental workflows are often complex, with multiple data sets that may contain large numbers of false positives. The representation of high-throughput data in the Gene Ontology (GO) therefore presents a challenging annotation problem, when the overarching goal of GO curation is to provide the most precise view of a gene's role in biology. To address this, representatives from annotation teams within the GO Consortium reviewed high-throughput data annotation practices. We present an annotation framework for high-throughput studies that will facilitate good standards in GO curation and, through the use of new high-throughput evidence codes, increase the visibility of these annotations to the research community.

Type: Article
Title: Annotation of gene product function from high-throughput studies using the Gene Ontology
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/database/baz007
Publisher version: http://doi.org/10.1093/database/baz007
Language: English
Additional information: Copyright © The Author(s) 2019. Published by Oxford University Press. Page 1 of 8 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: http://discovery.ucl.ac.uk/id/eprint/10067725
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