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Apomorphine in the treatment of Parkinson's disease: a review

Pessoa, RR; Moro, A; Munhoz, RP; Teive, HAG; Lees, AJ; (2018) Apomorphine in the treatment of Parkinson's disease: a review. Arquivos de Neuro-Psiquiatria , 76 (12) pp. 840-848. 10.1590/0004-282X20180140. Green open access

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Abstract

Optimizing idiopathic Parkinson's disease treatment is a challenging, multifaceted and continuous process with direct impact on patients' quality of life. The basic tenet of this task entails tailored therapy, allowing for optimal motor function with the fewest adverse effects. Apomorphine, a dopamine agonist used as rescue therapy for patients with motor fluctuations, with potential positive effects on nonmotor symptoms, is the only antiparkinsonian agent whose capacity to control motor symptoms is comparable to that of levodopa. Subcutaneous administration, either as an intermittent injection or as continuous infusion, appears to be the most effective and tolerable route. This review summarizes the historical background, structure, mechanism of action, indications, contraindications and side effects, compares apomorphine infusion therapy with other treatments, such as oral therapy, deep brain stimulation and continuous enteral infusion of levodopa/carbidopa gel, and gives practical instructions on how to initiate treatment.

Type: Article
Title: Apomorphine in the treatment of Parkinson's disease: a review
Location: Brazil
Open access status: An open access version is available from UCL Discovery
DOI: 10.1590/0004-282X20180140
Publisher version: http://doi.org/10.1590/0004-282X20180140
Language: English
Additional information: This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Apomorphine; dopaminer agents; Parkinsons disease; review
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/10067721
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