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Polarization of Myosin II Refines Tissue Material Properties to Buffer Mechanical Stress

Duda, M; Kirkland, NJ; Khalilgharibi, N; Tozluoglu, M; Yuen, AC; Carpi, N; Bove, A; ... Mao, Y; + view all (2019) Polarization of Myosin II Refines Tissue Material Properties to Buffer Mechanical Stress. Developmental Cell , 48 (2) 245-260.e7. 10.1016/j.devcel.2018.12.020. Green open access

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Abstract

As tissues develop, they are subjected to a variety of mechanical forces. Some of these forces are instrumental in the development of tissues, while others can result in tissue damage. Despite our extensive understanding of force-guided morphogenesis, we have only a limited understanding of how tissues prevent further morphogenesis once the shape is determined after development. Here, through the development of a tissue-stretching device, we uncover a mechanosensitive pathway that regulates tissue responses to mechanical stress through the polarization of actomyosin across the tissue. We show that stretch induces the formation of linear multicellular actomyosin cables, which depend on Diaphanous for their nucleation. These stiffen the epithelium, limiting further changes in shape, and prevent fractures from propagating across the tissue. Overall, this mechanism of force-induced changes in tissue mechanical properties provides a general model of force buffering that serves to preserve the shape of tissues under conditions of mechanical stress.

Type: Article
Title: Polarization of Myosin II Refines Tissue Material Properties to Buffer Mechanical Stress
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.devcel.2018.12.020
Publisher version: https://doi.org/10.1016/j.devcel.2018.12.020
Language: English
Additional information: © 2018 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Diaphanous, MyoII polarity, elasticity, force buffering, shape maintenance, stiffness, tissue mechanics
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > London Centre for Nanotechnology
URI: http://discovery.ucl.ac.uk/id/eprint/10067018
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