Barkhuizen, M;
van Mechelen, R;
Vermeer, M;
Chedraui, P;
Paes, D;
van den Hove, DLA;
Vaes, B;
... Gavilanes, AWD; + view all
(2019)
Systemic multipotent adult progenitor cells improve long-term neurodevelopmental outcomes after preterm hypoxic-ischemic encephalopathy.
Behavioural Brain Research
, 362
pp. 77-81.
10.1016/j.bbr.2019.01.016.
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Abstract
There is an urgent need for therapies that could reduce the disease burden of preterm hypoxic-ischemic encephalopathy. Here, we evaluate the long-term effects of multipotent adult progenitor cells (MAPC) on long-term behavioral outcomes in a preterm rat model of perinatal asphyxia. Rats of both sexes were treated with two doses of MAPCs within 24 h after the insult. Locomotor, cognitive and psychiatric impairments were evaluated starting at 1.5 (juvenile) and 6 months (adult). Hypoxia-ischemia affected locomotion, cognition, and anxiety in a sex-dependent manner, with higher vulnerability observed in males. The MAPC therapy partially attenuated deficits in object recognition memory in females of all tested ages, and in the adult males. The hypoxic insult caused delayed hyperactivity in adult males, which was corrected by MAPC therapy. These results suggest that MAPCs may have long-term benefits for neurodevelopmental outcome after preterm birth and global hypoxia-ischemia, which warrants further preclinical exploration.
| Type: | Article |
|---|---|
| Title: | Systemic multipotent adult progenitor cells improve long-term neurodevelopmental outcomes after preterm hypoxic-ischemic encephalopathy |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.bbr.2019.01.016 |
| Publisher version: | https://doi.org/10.1016/j.bbr.2019.01.016 |
| Language: | English |
| Additional information: | © 2019 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creative commons.org/licenses/BY-NC-ND/4.0/). |
| Keywords: | Hypoxic-ischemic encephalopathy, Neurodevelopment, Preterm brain, Stem cell therapy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Neonatology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10066932 |
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