Favuzzi, E;
Deogracias, R;
Marques-Smith, A;
Maeso, P;
Jezequel, J;
Exposito-Alonso, D;
Balia, M;
... Rico, B; + view all
(2019)
Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits.
Science
, 363
(6425)
pp. 413-417.
10.1126/science.aau8977.
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Favuzzi et al., Science 2019.pdf - Accepted Version Download (21MB) | Preview |
Abstract
How neuronal connections are established and organized into functional networks determines brain function. In the mammalian cerebral cortex, different classes of GABAergic interneurons exhibit specific connectivity patterns that underlie their ability to shape temporal dynamics and information processing. Much progress has been made toward parsing interneuron diversity, yet the molecular mechanisms by which interneuron-specific connectivity motifs emerge remain unclear. In this study, we investigated transcriptional dynamics in different classes of interneurons during the formation of cortical inhibitory circuits in mouse. We found that whether interneurons form synapses on the dendrites, soma, or axon initial segment of pyramidal cells is determined by synaptic molecules that are expressed in a subtype-specific manner. Thus, cell-specific molecular programs that unfold during early postnatal development underlie the connectivity patterns of cortical interneurons.
| Type: | Article |
|---|---|
| Title: | Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1126/science.aau8977 |
| Publisher version: | https://doi.org/10.1126/science.aau8977 |
| Language: | English |
| Additional information: | This is the author's version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science Journal Title {VOL#, (DATE)}, doi: doi number for your manuscript}. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10066873 |
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