Violari, A;
Cotton, MF;
Kuhn, L;
Schramm, DB;
Paximadis, M;
Loubser, S;
Shalekoff, S;
... Tiemessen, CT; + view all
(2019)
A unique perinatally HIV-infected child with long-term sustained virological control following antiretroviral treatment cessation.
Nature Communications
, 10
, Article 412. 10.1038/s41467-019-08311-0.
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Abstract
Understanding HIV remission in rare individuals who initiated antiretroviral therapy (ART) soon after infection and then discontinued, may inform HIV cure interventions. Here we describe features of virus and host of a perinatally HIV-1 infected child with long-term sustained virological control. The child received early limited ART in the Children with HIV Early antiRetroviral therapy (CHER) trial. At age 9.5 years, diagnostic tests for HIV are negative and the child has characteristics similar to uninfected children that include a high CD4:CD8 ratio, low T cell activation and low CCR5 expression. Virus persistence (HIV-1 DNA and plasma RNA) is confirmed with sensitive methods, but replication-competent virus is not detected. The child has weak HIV-specific antibody and T cell responses. Furthermore, we determine his HLA and KIR genotypes. This case aids in understanding post-treatment control and may help design of future intervention strategies.
| Type: | Article |
|---|---|
| Title: | A unique perinatally HIV-infected child with long-term sustained virological control following antiretroviral treatment cessation |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41467-019-08311-0 |
| Publisher version: | https://doi.org/10.1038/s41467-019-08311-0 |
| Language: | English |
| Additional information: | Copyright © The Author(s) 2019. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/ by/4.0/. |
| Keywords: | Antimicrobial responses, HIV infections, Paediatric research |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10066653 |
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