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Natural IgM antibodies in the immune defence against neoehrlichiosis

Wenneras, C; Goldblatt, D; Zancolli, M; Mattsson, M; Wass, L; Horkko, S; Rosen, A; (2017) Natural IgM antibodies in the immune defence against neoehrlichiosis. Infectious Diseases , 49 (11-12) pp. 809-816. 10.1080/23744235.2017.1347815. Green open access

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Abstract

Background: Neoehrlichiosis is an infectious disease caused by the tick-borne bacterium “Candidatus Neoehrlichia mikurensis”. Splenectomy and rituximab therapies are risk factors for severe neoehrlichiosis. Our aim was to examine if neoehrlichiosis patients had low levels of natural IgM antibodies and/or were hypogammaglobulinemic, and if such deficiencies were associated with asplenia and vascular complications. Methods: Neoehrlichiosis patients (n = 9) and control subjects (n = 10) were investigated for serum levels of IgG, IgA, and IgM, and for levels of natural IgM antibodies to pneumococcal polysaccharides (6B, 14), and to the malondialdehyde acetaldehyde epitope of oxidized LDL. The multivariate method Projection to Latent Structures was used to analyze the data. Results: The levels of natural IgM antibodies of various specificities were decreased or not measurable in half of the studied patients with neoehrlichiosis. Only one patient and one control subject were hypogammaglobulinemic. An inverse relationship was noted between the levels of natural IgM antibodies and the development of deep vein thrombosis. Unexpectedly, no association was seen between having or not having a spleen and the levels of natural IgM antibody levels in the circulation. Conclusions: Neither hypogammaglobulinemia nor lack of natural IgM antibodies alone predisposes for severe neoehrlichiosis. The importance of the spleen in the immune defence against Ca. N. mikurensis probably lies in its capacity to generate or maintain specific antibodies.

Type: Article
Title: Natural IgM antibodies in the immune defence against neoehrlichiosis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/23744235.2017.1347815
Publisher version: http://doi.org/10.1080/23744235.2017.1347815
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Candidatus Neoehrlichia mikurensis, natural IgM antibodies, malondialdehyde acetaldehyde epitope, pneumococci
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Developmental Neurosciences Prog
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Infect, Imm, Infla. and Physio Med
URI: http://discovery.ucl.ac.uk/id/eprint/10066446
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