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Evolutionary dynamics in pre-invasive neoplasia

Abbosh, C; Venkatesan, S; Janes, SM; Fitzgerald, RC; Swanton, C; (2017) Evolutionary dynamics in pre-invasive neoplasia. Current Opinion in System Biology , 2 pp. 1-8. 10.1016/j.coisb.2017.02.009. Green open access

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Abstract

Mutational processes occur in normal tissues from conception throughout life. Field cancerization describes the preconditioning of an area of epithelium to tumor growth. Pre-invasive lesions may arise in these fields, however only a minority of pre-invasive neoplasia progresses to overt malignancy. Within this review we discuss recent advances in our understanding of genomic instability processes in normal tissue, describe evolutionary dynamics in pre-invasive disease and highlight current evidence describing how increasing genomic instability may drive the transition from pre-invasive to invasive disease. Appreciation of the evolutionary rulebooks that operate in pre-invasive neoplasia may facilitate screening strategies, risk-stratification of pre-invasive lesions and precipitate novel preventative treatments in at-risk patient populations.

Type: Article
Title: Evolutionary dynamics in pre-invasive neoplasia
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.coisb.2017.02.009
Publisher version: https://doi.org/10.1016/j.coisb.2017.02.009
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Intratumor heterogeneity, genomic instability, cancer evolution, pre-invasive neoplasia, field cancerization
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: http://discovery.ucl.ac.uk/id/eprint/10066042
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