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Comparative proteomics reveals recruitment patterns of some protein families in the venoms of Cnidaria

Jaimes-Becerra, A; Chung, R; Morandini, AC; Weston, AJ; Padilla, G; Gacesa, R; Ward, M; ... Marques, AC; + view all (2017) Comparative proteomics reveals recruitment patterns of some protein families in the venoms of Cnidaria. Toxicon , 137 pp. 19-26. 10.1016/j.toxicon.2017.07.012. Green open access

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Abstract

Cnidarians are probably the oldest group of animals to be venomous, yet our current picture of cnidarian venom evolution is highly imbalanced due to limited taxon sampling. High-throughput tandem mass spectrometry was used to determine venom composition of the scyphozoan Chrysaora lactea and two cubozoans Tamoya haplonema and Chiropsalmus quadrumanus. Protein recruitment patterns were then compared against 5 other cnidarian venom proteomes taken from the literature. A total of 28 putative toxin protein families were identified, many for the first time in Cnidaria. Character mapping analysis revealed that 17 toxin protein families with predominantly cytolytic biological activities were likely recruited into the cnidarian venom proteome before the lineage split between Anthozoa and Medusozoa. Thereafter, venoms of Medusozoa and Anthozoa differed during subsequent divergence of cnidarian classes. Recruitment and loss of toxin protein families did not correlate with accepted phylogenetic patterns of Cnidaria. Selective pressures that drive toxin diversification independent of taxonomic positioning have yet to be identified in Cnidaria and now warrant experimental consideration.

Type: Article
Title: Comparative proteomics reveals recruitment patterns of some protein families in the venoms of Cnidaria
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.toxicon.2017.07.012
Publisher version: http://doi.org/10.1016/j.toxicon.2017.07.012
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Evolution, Venom, Cnidaria, Nematocysts, Proteomics
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > SoP Pharmaceutical and Bio Chemistry
URI: http://discovery.ucl.ac.uk/id/eprint/10065672
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