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Early Retinal Findings Following Cooling in Neonatal Encephalopathy

Akin, MA; Sahin, O; Cansever, M; Sirakaya, E; Robertson, NJ; (2018) Early Retinal Findings Following Cooling in Neonatal Encephalopathy. Neuropediatrics 10.1055/s-0038-1669425.

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Abstract

BACKGROUND AND AIM:  Perinatal HI (hypoxia-ischemia)-related visual defects including blindness are known to be associated with ischemic lesions in intracerebral visual pathways and ischemic retinal damage (IRD). Intraocular hemorrhages (IOH) such as retinal hemorrhage (RH), which may result from perinatal HI, can cause IRD by various mechanisms. We aimed to evaluate the early retinal findings in neonates with moderate-to-severe neonatal encephalopathy (NE) who underwent TH and its relationship between coagulation status, amplitude-integrated electroencephalography (aEEG) patterns, and magnetic resonance imaging-magnetic resonance spectroscopy (MRI-MRS) findings. METHOD AND PATIENTS:  A total of 31 newborn infants who underwent moderate-to-severe NE and TH included in the study. Coagulation parameters were taken immediately before starting TH, and daily during TH period. aEEG records were obtained during TH and rewarming period.Binocular indirect ophthalmoscopic examination (BIOE) and MRI-MRS scanning were performed when TH protocol completed. RESULTS:  Total 13 (41.9%) patients had abnormal BIOE findings. Ten of them were (77%) IOH, other findings are as follows: RH (n = 7), optic disc hemorrhage (n = 2), and vitreous hemorrhage (n = 1). Initial coagulation status was not related to IOH. Worsened aEEG and MRI-MRS results were not related to BIOE findings. CONCLUSION:  Frequency of IOH is high in newborns with NE who underwent TH being independent from severity of MRS-MRI findings, aEEG pattern, and disturbed coagulation status.

Type: Article
Title: Early Retinal Findings Following Cooling in Neonatal Encephalopathy
DOI: 10.1055/s-0038-1669425
Publisher version: https://doi.org/10.1055/s-0038-1669425
Language: English
Additional information: This version is the version of the record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: hypothermia, perinatal hypoxia–ischemia, newborn, retinal hemorrhage
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health > Neonatology
URI: http://discovery.ucl.ac.uk/id/eprint/10065614
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