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Irreversible electroporation in primary and metastatic hepatic malignancies A review

Lyu, T; Wang, X; Su, Z; Shangguan, J; Sun, C; Figini, M; Wang, J; ... Zhang, Z; + view all (2017) Irreversible electroporation in primary and metastatic hepatic malignancies A review. [Review]. Medicine , 96 (17) , Article e6386. 10.1097/MD.0000000000006386. Green open access

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Abstract

Background: Liver cancer makes up a huge percentage of cancer mortality worldwide. Irreversible electroporation (IRE) is a relatively new minimally invasive nonthermal ablation technique for tumors that applies short pulses of high frequency electrical energy to irreversibly destabilize cell membrane to induce tumor cell apoptosis. Methods: This review aims to investigate the studies regarding the use of IRE treatment in liver tumors and metastases to liver. We searched PubMed for all of IRE relevant English language articles published up to September 2016. They included clinical trials, experimental studies, observational studies, and reviews. This review manuscript is nothing with ethics issues and ethical approval is not provided. Results: In recent years, increasingly more studies in both preclinical and clinical settings have been conducted to examine the safety and efficacy of this new technique, shedding light on the crucial advantages and disadvantages that IRE possesses. Unlike the current leading thermal ablation techniques, such as radiofrequency ablation (RFA), microwave ablation (MWA), and cryoablation, IRE requires shorter ablation time without damaging adjacent important vital structures. Conclusion: Although IRE has successfully claimed its valuable status in the field of hepatic cancer treatment both preclinical and clinical settings. In order to systemically test and establish its safety and efficacy for clinical applications, more studies still need to be conducted.

Type: Article
Title: Irreversible electroporation in primary and metastatic hepatic malignancies A review
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/MD.0000000000006386
Publisher version: https://doi.org/10.1097/MD.0000000000006386
Language: English
Additional information: Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the Creative Commons Attribution-No Derivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author.
Keywords: hepatocellular carcinoma, irreversible electroporation, liver metastases, primary liver tumor, tumor ablation
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: http://discovery.ucl.ac.uk/id/eprint/10065607
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