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Pre-diagnosis diet and survival after a diagnosis of ovarian cancer

Playdon, MC; Nagle, CM; Ibiebele, TI; Ferrucci, LM; Protani, MM; Carter, J; Hyde, SE; ... Webb, PM; + view all (2017) Pre-diagnosis diet and survival after a diagnosis of ovarian cancer. British Journal of Cancer , 116 (12) pp. 1627-1637. 10.1038/bjc.2017.120. Green open access

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Abstract

BACKGROUND: The relationship between diet and survival after ovarian cancer diagnosis is unclear as a result of a limited number of studies and inconsistent findings. METHODS: We examined the association between pre-diagnostic diet and overall survival in a population-based cohort (n=811) of Australian women diagnosed with invasive epithelial ovarian cancer between 2002 and 2005. Diet was measured by validated food frequency questionnaire. Deaths were ascertained up to 31 August 2014 via medical record review and Australian National Death Index linkage. We conducted Cox proportional hazards regression analysis, controlling for diagnosis age, tumour stage, grade and subtype, residual disease, smoking status, body mass index, physical activity, marital status, and energy intake. RESULTS: We observed improved survival with highest compared with lowest quartile of fibre intake (hazard ratio (HR)=0.69, 95% CI: 0.53-0.90, P-trend=0.002). There was a suggestion of better survival for women with highest compared with lowest intake category of green leafy vegetables (HR=0.79, 95% CI: 0.62-0.99), fish (HR=0.74, 95% CI: 0.57-0.95), poly- to mono-unsaturated fat ratio (HR=0.76, 95% CI: 0.59-0.98), and worse survival with higher glycaemic index (HR=1.28, 95% CI: 1.01-1.65, P-trend=0.03). CONCLUSIONS: The associations we observed between healthy components of diet pre-diagnosis and ovarian cancer survival raise the possibility that dietary choices after diagnosis may improve survival.

Type: Article
Title: Pre-diagnosis diet and survival after a diagnosis of ovarian cancer
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/bjc.2017.120
Publisher version: https://doi.org/10.1038/bjc.2017.120
Language: English
Additional information: From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
Keywords: Aged, Australia, Cohort Studies, Diet, Dietary Fats, Unsaturated, Dietary Fiber, Fatty Acids, Monounsaturated, Female, Glycemic Index, Humans, Middle Aged, Neoplasm Invasiveness, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Proportional Hazards Models, Seafood, Surveys and Questionnaires, Survival Rate, Vegetables
URI: http://discovery.ucl.ac.uk/id/eprint/10065497
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