Lichman, BR;
Lamming, ED;
Pesnot, T;
Smith, JM;
Hailes, HC;
Ward, JM;
(2014)
One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine.
Green Chemistry
, 17
(2)
pp. 852-855.
10.1039/c4gc02325k.
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Abstract
We describe novel chemoenzymatic routes to (S)-benzylisoquinoline and (S)-tetrahydroprotoberberine alkaloids using the enzymes transaminase (TAm) and norcoclaurine synthase (NCS) in a one-pot, one-substrate ‘triangular’ cascade. Employment of up to two C–C bond forming steps allows for the rapid generation of molecular complexity under mild conditions.
| Type: | Article |
|---|---|
| Title: | One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c4gc02325k |
| Publisher version: | https://doi.org/10.1039/c4gc02325k |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 3.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/ |
| Keywords: | Science & Technology, Physical Sciences, Chemistry, Multidisciplinary, GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY, Chemistry, Science & Technology - Other Topics, ENGINEERED ESCHERICHIA-COLI, PICTET-SPENGLER REACTION, BENZYLISOQUINOLINE ALKALOIDS, ORGANIC-SYNTHESIS, SACCHAROMYCES-CEREVISIAE, ASYMMETRIC-SYNTHESIS, TETRAHYDROISOQUINOLINES, TETRAHYDROPAPAVEROLINE, MORPHINE, BIOTRANSFORMATION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10065063 |
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