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Transmissible human proteopathies: an expanding field

Jaunmuktane, Z; Brandner, S; (2018) Transmissible human proteopathies: an expanding field. Diagnostic Histopathology 10.1016/j.mpdhp.2018.11.002. (In press).

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Abstract

Prions are considered the prototype of transmissible proteopathies, and this property has for many decades been considered unique. More recently the transmissibility of other misfolded proteins, notably Aβ tau and synuclein, has been recognized. Initially, the transmission of these proteins was shown experimentally but the relevance for humans was debated. The co-transmission of Aβ with prions through medical procedures involving preparations derived from cadaveric human tissues, such as human growth hormone treatment, dura mater transplants or the use of neurosurgical instruments carrying traces of Aβ protein has fundamentally changed the opinion in the field. In this article, we will summarize the key features of the most common neurodegenerative diseases involving protein misfolding and their established or potential role in disease transmission.

Type: Article
Title: Transmissible human proteopathies: an expanding field
DOI: 10.1016/j.mpdhp.2018.11.002
Publisher version: http://doi.org/10.1016/j.mpdhp.2018.11.002
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: a-synuclein; Alzheimer’s disease; amyloid-b; CJD;Creutzfeldt-Jakob disease; neurodegeneration; neurodegenerativedisease; Parkinson’s disease; prion disease; prions; proteopathy; tau;tauopathy
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: http://discovery.ucl.ac.uk/id/eprint/10064997
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