Gustot, T;
Kamath, P;
Jalan, R;
(2019)
Acute-on-chronic liver failure in patients with alcohol-related liver disease.
Journal of Hepatology
, 70
(2)
pp. 319-327.
10.1016/j.jhep.2018.12.008.
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Abstract
The spectrum of alcohol-related liver diseases (ALD) includes steatosis, steatohepatitis, progressive liver fibrosis, and cirrhosis. Acute-on-chronic liver failure (ACLF) is a recently defined entity that occurs in patients with chronic liver diseases and is characterised by acute decompensation, organ failures and a high risk of short-term mortality. Active alcohol consumption, alcoholic hepatitis and bacterial infections are the most frequent events precipitating the development of ACLF in the context of ALD (ALD-ACLF). The specific management of this entity remains unknown and the place of salvage liver transplantation controversial. This overview details the current knowledge on specific aspects of epidemiology, pathophysiology, prognosis and management of ALD-ACLF.
| Type: | Article |
|---|---|
| Title: | Acute-on-chronic liver failure in patients with alcohol-related liver disease |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jhep.2018.12.008 |
| Publisher version: | https://doi.org/10.1016/j.jhep.2018.12.008 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Cirrhosis, Organ failure, Inflammation, Alcoholic hepatitis, Infection, Liver transplantation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10064967 |
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