Lamberink, HJ;
Geleijns, K;
Otte, WM;
Arzimanoglou, A;
Cross, JH;
Korff, CM;
Ramantani, G;
(2018)
Why the TimeToStop trial failed to recruit: a survey on antiepileptic drug withdrawal after paediatric epilepsy surgery.
Epileptic Disorders
, 20
(5)
pp. 374-385.
10.1684/epd.2018.1003.
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Abstract
Following the results of the multicentre European retrospective “TimeToStop” cohort study, we initiated a randomised trial to determine cognitive benefits of early postoperative antiepileptic drug withdrawal. Unfortunately, the trial failed to recruit and was terminated, as almost all parents preferred early drug withdrawal. The objectives of the current survey were to obtain insight into current practices regarding drug withdrawal after paediatric epilepsy surgery among epileptologists, and better understand the reasons for difficulties in recruitment.
| Type: | Article |
|---|---|
| Title: | Why the TimeToStop trial failed to recruit: a survey on antiepileptic drug withdrawal after paediatric epilepsy surgery |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1684/epd.2018.1003 |
| Publisher version: | http://www.jle.com/10.1684/epd.2018.1003 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10064806 |
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