Dolphin, A;
(2018)
Voltage-gated calcium channel α2δ subunits: an assessment of proposed novel roles.
F1000Research
, 2018
(7)
, Article 1830. 10.12688/f1000research.16104.1.
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Abstract
Voltage-gated calcium (Ca V ) channels are associated with β and α 2 δ auxiliary subunits. This review will concentrate on the function of the α 2 δ protein family, which has four members. The canonical role for α 2 δ subunits is to convey a variety of properties on the Ca V 1 and Ca V 2 channels, increasing the density of these channels in the plasma membrane and also enhancing their function. More recently, a diverse spectrum of non-canonical interactions for α 2 δ proteins has been proposed, some of which involve competition with calcium channels for α 2 δ or increase α 2 δ trafficking and others which mediate roles completely unrelated to their calcium channel function. The novel roles for α 2 δ proteins which will be discussed here include association with low-density lipoprotein receptor-related protein 1 (LRP1), thrombospondins, α-neurexins, prion proteins, large conductance (big) potassium (BK) channels, and N -methyl-d-aspartate (NMDA) receptors.
Type: | Article |
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Title: | Voltage-gated calcium channel α2δ subunits: an assessment of proposed novel roles |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.12688/f1000research.16104.1 |
Publisher version: | https://doi.org/10.12688/f1000research.16104.1 |
Language: | English |
Additional information: | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | calcium channel, alpha2delta, interaction |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology |
URI: | https://discovery.ucl.ac.uk/id/eprint/10063999 |
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