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Post-mortem magnetic resonance (PMMR) imaging of the brain in fetuses and children with histopathological correlation

Shelmerdine, SC; Hutchinson, JC; Sebire, NJ; Jacques, TS; Arthurs, OJ; (2017) Post-mortem magnetic resonance (PMMR) imaging of the brain in fetuses and children with histopathological correlation. Clinical Radiology , 72 (12) pp. 1025-1037. 10.1016/j.crad.2017.07.015. Green open access

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Abstract

Post-mortem magnetic resonance (PMMR) imaging is rapidly emerging as an alternative, “less invasive”, and more widely accepted investigative approach for perinatal deaths in the UK. PMMR has a high diagnostic accuracy for congenital and acquired fetal neuropathological anomalies compared to conventional autopsy, and is particularly useful when autopsy is non-diagnostic. The main objectives of this review are to describe and illustrate the range of common normal and abnormal central nervous system (CNS) findings encountered during PMMR investigation. This article covers the standard PMMR sequences used at our institution, normal physiological post-mortem findings, and a range of abnormal developmental and acquired conditions. The abnormal findings include diseases ranging from neural tube defects, posterior fossa malformations, those of forebrain and commissural development as well as neoplastic, haemorrhagic, and infectious aetiologies. Neuropathological findings at conventional autopsy accompany many of the conditions we describe, allowing readers to better understand the underlying disease processes and imaging appearances.

Type: Article
Title: Post-mortem magnetic resonance (PMMR) imaging of the brain in fetuses and children with histopathological correlation
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.crad.2017.07.015
Publisher version: https://doi.org/10.1016/j.crad.2017.07.015
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Development Bio and Cancer Prog
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Developmental Neurosciences Prog
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Pop, Policy and Practice Prog
URI: http://discovery.ucl.ac.uk/id/eprint/10063761
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