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MRI-guidance for motion management in external beam radiotherapy: current status and future challenges

Paganelli, C; Whelan, B; Peroni, M; Summers, P; Fast, M; van de Lindt, T; McClelland, J; ... Baroni, G; + view all (2018) MRI-guidance for motion management in external beam radiotherapy: current status and future challenges. Physics in Medicine and Biology , 63 (22) 10.1088/1361-6560/aaebcf.

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Abstract

High precision conformal radiotherapy requires sophisticated imaging techniques to aid in target localisation for planning and treatment, particularly when organ motion due to respiration is involved. X-ray based imaging is a well-established standard for radiotherapy treatments. Over the last few years, the ability of magnetic resonance imaging (MRI) to provide radiation-free images with high-resolution and superb soft tissue contrast has highlighted the potential of this imaging modality for radiotherapy treatment planning and motion management. In addition, these advantageous properties motivated several recent developments towards combined MRI radiation therapy treatment units, enabling in-room MRI-guidance and treatment adaptation. The aim of this review is to provide an overview of the state-of-the-art in MRI-based image guidance for organ motion management in external beam radiotherapy. Methodological aspects of MRI for organ motion management are reviewed and their application in treatment planning, in-room guidance and adaptive radiotherapy described. Finally, a roadmap for an optimal use of MRI-guidance is highlighted and future challenges are discussed.

Type: Article
Title: MRI-guidance for motion management in external beam radiotherapy: current status and future challenges
DOI: 10.1088/1361-6560/aaebcf
Publisher version: https://doi.org/10.1088/1361-6560/aaebcf
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: http://discovery.ucl.ac.uk/id/eprint/10063623
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