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Microstructural Analysis of Cardiac Endomyocardial Biopsies with Synchrotron Radiation-Based X-Ray Phase Contrast Imaging

Dejea, H; Garcia-Canadilla, P; Stampanoni, M; Zamora, M; Crispi, F; Bijnens, B; Bonnin, A; (2017) Microstructural Analysis of Cardiac Endomyocardial Biopsies with Synchrotron Radiation-Based X-Ray Phase Contrast Imaging. In: Pop, M and Wright, GA, (eds.) Functional Imaging and Modelling of the Heart: 9th International Conference, FIMH 2017, Toronto, ON, Canada, June 11-13, 2017, Proceedings. (pp. pp. 23-31). Springer: Cham, Switzerland. Green open access

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Abstract

Nowadays, unexplained cardiovascular diseases (CVD) and heart transplant response are assessed by qualitative histological analysis of extracted endomyocardial biopsies (EMB), which is a time consuming procedure involving structural damage of the tissue and the analysis in only a few slices of a 3D structure. In this paper we propose synchrotron radiation-based X-ray phase contrast imaging (X-PCI) as a suitable technique for the analysis of different cardiac microstructures, such as collagen matrix, cardiomyocytes and microvasculature, and how they are affected in abnormal conditions. Following an established procedure in clinics, biopsies from Wistar Kyoto rats are extracted, imaged with X-PCI, and processed in order to show that the quantification of the endomysial collagen matrix, cardiomyocytes and microvasculature is possible, thus demonstrating that the intrinsic properties of X-PCI make it a powerful technique for cardiac microstructure imaging and a promising methodology for a faster and more accurate EMB analysis for CVD diagnosis and evaluation.

Type: Proceedings paper
Title: Microstructural Analysis of Cardiac Endomyocardial Biopsies with Synchrotron Radiation-Based X-Ray Phase Contrast Imaging
Event: FIMH: International Conference on Functional Imaging and Modeling of the Heart
ISBN-13: 9783319594477
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/978-3-319-59448-4_3
Publisher version: https://doi.org/10.1007/978-3-319-59448-4_3
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cardiac microstructure, Cardiac endomyocardial biopsy, X-ray tomography, Phase contrast imaging
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Children's Cardiovascular Disease
URI: http://discovery.ucl.ac.uk/id/eprint/10063580
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