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The spectrum of psychosis in multiple sclerosis: a clinical case series

Gilberthorpe, TG; O'Connell, KE; Carolan, A; Silber, E; Brex, PA; Sibtain, NA; David, AS; (2017) The spectrum of psychosis in multiple sclerosis: a clinical case series. Neuropsychiatric Disease and Treatment , 13 pp. 303-318. 10.2147/NDT.S116772. Green open access

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Abstract

Psychosis in the context of multiple sclerosis (MS) has previously been reported as a rare occurrence. However, recent epidemiological studies have found prevalence rates of psychosis in MS that are two to three times higher than those in the general population. Untreated psychosis in patients with MS can adversely impact on adherence to MS medication, levels of disability, and quality of life. This retrospective case series describes the spectrum of psychotic disorders occurring in association with MS using demographic, clinical, and neuroimaging data. In the discussion, we highlight the particular diagnostic and treatment challenges that such disorders can pose for clinicians and through our case vignettes provide examples of potential interventions for this complex patient population.

Type: Article
Title: The spectrum of psychosis in multiple sclerosis: a clinical case series
Open access status: An open access version is available from UCL Discovery
DOI: 10.2147/NDT.S116772
Publisher version: https://doi.org/10.2147/NDT.S116772
Language: English
Additional information: This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
Keywords: psychosis, multiple sclerosis, neuropsychiatric, cognitive, schizophrenia-like, demyelination
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: http://discovery.ucl.ac.uk/id/eprint/10063512
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