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When change is the only constant: The promise of longitudinal neuroimaging in understanding social anxiety disorder.

Haller, SPW; Mills, KL; Hartwright, CE; David, AS; Cohen Kadosh, K; (2018) When change is the only constant: The promise of longitudinal neuroimaging in understanding social anxiety disorder. Dev Cogn Neurosci , 33 pp. 73-82. 10.1016/j.dcn.2018.05.005. Green open access

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Abstract

Longitudinal studies offer a unique window into developmental change. Yet, most of what we know about the pathophysiology of psychiatric disorders is based on cross-sectional work. Here, we highlight the importance of adopting a longitudinal approach in order to make progress towards identifying the neurobiological mechanisms of social anxiety disorder (SAD). Using examples, we illustrate how longitudinal data can uniquely inform SAD etiology and timing of interventions. The brain's inherently adaptive quality requires that we model risk correlates of disorders as dynamic in their expression. Developmental theories regarding timing of environmental events, cascading effects and (mal)adaptations of the developing brain will be crucial components of comprehensive, integrative models of SAD. We close by discussing analytical considerations when working with longitudinal, developmental data.

Type: Article
Title: When change is the only constant: The promise of longitudinal neuroimaging in understanding social anxiety disorder.
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.dcn.2018.05.005
Keywords: Adolescence, Development, Longitudinal imaging, Psychopathology, Social anxiety, fMRI
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: http://discovery.ucl.ac.uk/id/eprint/10063446
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