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A Differential Electrochemical Readout ASIC With Heterogeneous Integration of Bio-Nano Sensors for Amperometric Sensing

Ghoreishizadeh, SS; Taurino, I; De Micheli, G; Carrara, S; Georgiou, P; (2017) A Differential Electrochemical Readout ASIC With Heterogeneous Integration of Bio-Nano Sensors for Amperometric Sensing. IEEE Transactions on Biomedical Circuits and Systems , 11 (5) pp. 1148-1159. 10.1109/TBCAS.2017.2733624. Green open access

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Abstract

A monolithic biosensing platform is presented for miniaturized amperometric electrochemical sensing in CMOS. The system consists of a fully integrated current readout circuit for differential current measurement as well as on-die sensors developed by growing platinum nanostructures (Pt-nanoS) on top of electrodes implemented with the top metal layer. The circuit is based on the switch-capacitor technique and includes pseudodifferential integrators for concurrent sampling of the differential sensor currents. The circuit further includes a differential to single converter and a programmable gain amplifier prior to an ADC. The system is fabricated in 0.35 μm technology and measures current within ±20 μA with minimum input-referred noise of 0.47 pA and consumes 9.3 mW from a 3.3 V supply. Differential sensing for nanostructured sensors is proposed to build highly sensitive and offsetfree sensors for metabolite detection. This is successfully tested for bio-nano-sensors for the measurement of glucose in submilli molar concentrations with the proposed readout IC. The on-die electrodes are nanostructured and cyclic voltammetry run successfully through the readout IC to demonstrate detection of H2 O2.

Type: Article
Title: A Differential Electrochemical Readout ASIC With Heterogeneous Integration of Bio-Nano Sensors for Amperometric Sensing
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/TBCAS.2017.2733624
Publisher version: https://doi.org/10.1109/TBCAS.2017.2733624
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Current measurement, Clocks, Biosensors, Multiplexing, Biomedical measurement, Sugar
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
URI: http://discovery.ucl.ac.uk/id/eprint/10063265
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