UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Clinical Course of Autosomal Recessive Bestrophinopathy Complicated by Choroidal Neovascularization

Introini, U; Casalino, G; Khan, KN; Eandi, C; Alovisi, C; Michaelides, M; Bandello, F; (2018) Clinical Course of Autosomal Recessive Bestrophinopathy Complicated by Choroidal Neovascularization. Ophthalmic Surgery, Lasers and Imaging Retina , 49 (11) pp. 888-892. 10.3928/23258160-20181101-10.

[img] Text
Michaelides_Case series_final_clean.pdf - ["content_typename_Accepted version" not defined]
Access restricted to UCL open access staff

Download (147kB)

Abstract

The authors report the clinical course of two cases of autosomal recessive bestrophinopathy (ARB) complicated by choroidal neovascularization (CNV). One patient presenting with a novel BEST1 mutation (c.658 C>T, p.Gln220*) underwent anti-vascular endothelial growth factor therapy. Response to treatment was documented on optical coherence tomography angiography (OCTA). Despite initial response to treatment, recurrent CNV exudation with progressive subretinal fibrosis was observed. In the second patient, the CNV was not treated and spontaneous regression was observed. This report indicates that the clinical course of CNV in ARB may vary considerably, ranging from spontaneous regression to progressive subretinal fibrosis despite intervention.

Type: Article
Title: Clinical Course of Autosomal Recessive Bestrophinopathy Complicated by Choroidal Neovascularization
Location: United States
DOI: 10.3928/23258160-20181101-10
Publisher version: https://doi.org/10.3928/23258160-20181101-10
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: http://discovery.ucl.ac.uk/id/eprint/10063085
Downloads since deposit
1Download
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item