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Clinical Course of Autosomal Recessive Bestrophinopathy Complicated by Choroidal Neovascularization

Introini, U; Casalino, G; Khan, KN; Eandi, C; Alovisi, C; Michaelides, M; Bandello, F; (2018) Clinical Course of Autosomal Recessive Bestrophinopathy Complicated by Choroidal Neovascularization. Ophthalmic Surgery, Lasers and Imaging Retina , 49 (11) pp. 888-892. 10.3928/23258160-20181101-10.

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Abstract

The authors report the clinical course of two cases of autosomal recessive bestrophinopathy (ARB) complicated by choroidal neovascularization (CNV). One patient presenting with a novel BEST1 mutation (c.658 C>T, p.Gln220*) underwent anti-vascular endothelial growth factor therapy. Response to treatment was documented on optical coherence tomography angiography (OCTA). Despite initial response to treatment, recurrent CNV exudation with progressive subretinal fibrosis was observed. In the second patient, the CNV was not treated and spontaneous regression was observed. This report indicates that the clinical course of CNV in ARB may vary considerably, ranging from spontaneous regression to progressive subretinal fibrosis despite intervention.

Type: Article
Title: Clinical Course of Autosomal Recessive Bestrophinopathy Complicated by Choroidal Neovascularization
Location: United States
DOI: 10.3928/23258160-20181101-10
Publisher version: https://doi.org/10.3928/23258160-20181101-10
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10063085
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