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Poroelasticity of Living Tissues

Malandrino, A; Moeendarbary, E; (2019) Poroelasticity of Living Tissues. In: Narayan, R, (ed.) Encyclopedia of Biomedical Engineering. (pp. 238-245). Elsevier: Amsterdam, Netherlands.

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Abstract

Nature presents to us a plethora of materials composed by mixtures of finely assembled phases, the most abundant in biology being the fluid phase that mainly comprises of water. Physical interactions of water with other phases are fundamental to describe many systems, including living materials. The theory of poroelasticity provides a way to describe the mechanical behavior resulting from these hydraulic effects, by modeling a porous medium consisting of an elastic solid skeleton infiltrated by fluid-saturated interlinked pores. This powerful approach can relate microstructural parameters, phases, and interactions, to scaled-up continuum mechanical properties measurable with experiments. Following presentation of basic poroelastic equations, we present how this theoretical framework is relevant for robust mechanical modeling of tissues and cells, providing compositional and structural idealizations to characterize viscoelastic responses via realistic, physical, and measurable parameters.

Type: Book chapter
Title: Poroelasticity of Living Tissues
ISBN-13: 978-0-12-805144-3
DOI: 10.1016/B978-0-12-801238-3.99932-X
Publisher version: https://doi.org/10.1016/B978-0-12-801238-3.99932-X
Language: English
Keywords: Atomic force microscopy, Biomechanical properties, Biphasic theory, Cell mechanics, Confined compression, Drained and undrained properties, Experimental techniques, Poroelasticity, Poromechanics, Porous continuum, Tissue mechanics
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10063014
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