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The Role of Aneuploidy in Cancer Evolution

Sansregret, L; Swanton, C; (2017) The Role of Aneuploidy in Cancer Evolution. Cold Spring Harbor Perspectives in Medicine , 7 (1) , Article a028373. 10.1101/cshperspect.a028373. Green open access

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Abstract

Chromosomal aberrations during cell division represent one of the first recognized features of human cancer cells, and modern detection methods have revealed the pervasiveness of aneuploidy in cancer. The ongoing karyotypic changes brought about by chromosomal instability (CIN) contribute to tumor heterogeneity, drug resistance, and treatment failure. Whole-chromosome and segmental aneuploidies resulting from CIN have been proposed to allow “macroevolutionary” leaps that may contribute to profound phenotypic change. In this review, we will outline evidence indicating that aneuploidy and CIN contribute to cancer evolution.

Type: Article
Title: The Role of Aneuploidy in Cancer Evolution
Open access status: An open access version is available from UCL Discovery
DOI: 10.1101/cshperspect.a028373
Publisher version: http://dx.doi.org/10.1101/cshperspect.a028373
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/10062860
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