Sarma, GP;
Lee, CW;
Portegys, T;
Ghayoomie, V;
Jacobs, T;
Alicea, B;
Cantarelli, M;
... Larson, SD; + view all
(2018)
OpenWorm: overview and recent advances in integrative biological simulation of Caenorhabditis elegans.
Philosophical Transactions of the Royal Society B:Biological Sciences
, 373
(1758)
10.1098/rstb.2017.0382.
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Abstract
The adoption of powerful software tools and computational methods from the software industry by the scientific research community has resulted in a renewed interest in integrative, large-scale biological simulations. These typically involve the development of computational platforms to combine diverse, process-specific models into a coherent whole. The OpenWorm Foundation is an independent research organization working towards an integrative simulation of the nematode Caenorhabditis elegans, with the aim of providing a powerful new tool to understand how the organism's behaviour arises from its fundamental biology. In this perspective, we give an overview of the history and philosophy of OpenWorm, descriptions of the constituent sub-projects and corresponding open-science management practices, and discuss current achievements of the project and future directions. This article is part of a discussion meeting issue ‘Connectome to behaviour: modelling C. elegans at cellular resolution’.
| Type: | Article |
|---|---|
| Title: | OpenWorm: overview and recent advances in integrative biological simulation of Caenorhabditis elegans |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1098/rstb.2017.0382 |
| Publisher version: | https://doi.org/10.1098/rstb.2017.0382 |
| Language: | English |
| Additional information: | Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
| Keywords: | computational neuroscience, bioinformatics,software engineering, computational physiology,biological simulation, Caenorhabditis elegans |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10062682 |
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