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Motor cortical excitability during voluntary inhibition of involuntary tic movements

Ganos, C; Rocchi, L; Latorre, A; Hockney, L; Palmer, C; Joyce, E; Bhatia, K; ... Rothwell, J; + view all (2018) Motor cortical excitability during voluntary inhibition of involuntary tic movements. Movement Disorders , 33 (11) pp. 1804-1809. 10.1002/mds.27479.

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Abstract

BACKGROUND: Tics can be voluntarily inhibited. However, the neurophysiology of voluntary tic inhibition remains underexplored. The objective of this study was to explore state‐dependent effects of voluntary tic inhibition on M1 excitability. METHODS: Neurophysiological assessments (single motor‐evoked potentials, corticospinal recruitment curves, short‐interval intracortical inhibition, H‐reflex) were performed in 14 adults with Tourette syndrome during voluntary tic inhibition and free ticcing. Regressions between behavioral performance and neurophysiological measures were also performed. RESULTS: Voluntary tic inhibition reduced corticospinal excitability: the greater the ability to inhibit tics, the greater was the reduction in excitability. Voluntary tic inhibition was not associated with changes in the excitability of short‐interval intracortical inhibition or the H‐reflex. CONCLUSIONS: Voluntary inhibition of tics reduces the excitability of corticospinal output. The pattern of neurophysiological findings is consistent with a withdrawal of excitation, but not with modulation of the inhibitory interneuronal mechanisms involved in short‐interval intracortical inhibition.

Type: Article
Title: Motor cortical excitability during voluntary inhibition of involuntary tic movements
Location: Hong Kong, HONG KONG
DOI: 10.1002/mds.27479
Publisher version: https://doi.org/10.1002/mds.27479
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: motor cortical excitability, tic disorders, transcranial magnetic stimulation, voluntary motor control, voluntary tic inhibition
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/10062072
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