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Vitamin D supplementation and neurofilament light chain in multiple sclerosis

Holmøy, T; Røsjø, E; Zetterberg, H; Blennow, K; Lindstrøm, JC; Steffensen, LH; Kampman, MT; (2018) Vitamin D supplementation and neurofilament light chain in multiple sclerosis. Acta Neurologica Scandinavica 10.1111/ane.13037. (In press).

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Abstract

OBJECTIVES: The effect of vitamin D supplementation on the disease course of multiple sclerosis (MS) is not established. Neurofilament light chain (NFL) is a sensitive marker of axonal degeneration. The aim of this study was to establish whether high-dose vitamin D supplementation reduces serum levels of NFL. MATERIALS AND METHODS: We have performed a 96 weeks placebo-controlled randomized study of weekly supplementation with 20.000 IU vitamin D3 in 71 patients with relapsing remitting MS (RRMS). Serum levels of NFL were measured at baseline, week 48 and week 96 with a single molecule (Simoa) assay in 69 of these patients. RESULTS: Serum levels of 25-hydroxyvitamin D more than doubled in the vitamin D group. Compared to placebo, vitamin D supplementation had no overall effect on the change in serum levels of NFL from baseline (p=0.93 at week 48 and p=0.56 at week 96). In the subgroup of patients not receiving disease-modifying therapy, NFL decreased by 30.9% to week 48 and 32.6% to week 96 from baseline in the vitamin D group as compared to the placebo group (p=0.06 for both time points). CONCLUSION: With a possible exception for patients not treated with disease-modifying drugs, weekly supplementation with 20.000 IU vitamin D3 did not affect NFL levels in these RRMS patients. This article is protected by copyright. All rights reserved.

Type: Article
Title: Vitamin D supplementation and neurofilament light chain in multiple sclerosis
Location: Denmark
DOI: 10.1111/ane.13037
Publisher version: https://doi.org/10.1111/ane.13037
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Multiple sclerosis, clinical trial, neurofilament light chain, vitamin D
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: http://discovery.ucl.ac.uk/id/eprint/10061207
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