Sandelius, A;
Portelius, E;
Kallen, A;
Zetterberg, H;
Rot, U;
Olsson, B;
Toledo, JB;
... Blennow, K; + view all
(2019)
Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology.
Alzheimer's & Dementia
, 15
(1)
pp. 55-64.
10.1016/j.jalz.2018.08.006.
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Abstract
Introduction: The level of the presynaptic protein growth-associated protein 43 (GAP-43) in cerebrospinal fluid (CSF) has previously been shown to be increased in Alzheimer's disease (AD) and thus may serve as an outcome measure in clinical trials and facilitate earlier disease detection. / Methods: We developed an enzyme-linked immunosorbent assay for CSF GAP-43 and measured healthy controls (n = 43), patients with AD (n = 275), or patients with other neurodegenerative diseases (n = 344). In a subpopulation (n = 93), CSF GAP-43 concentrations from neuropathologically confirmed cases were related to Aβ plaques, tau, α-synuclein, and TDP-43 pathologies. / Results: GAP-43 was significantly increased in AD compared to controls and most neurodegenerative diseases and correlated with the magnitude of neurofibrillary tangles and Aβ plaques in the hippocampus, amygdala, and cortex. GAP-43 was not associated to α-synuclein or TDP-43 pathology. / Discussion: The presynaptic marker GAP-43 is associated with both diagnosis and neuropathology of AD and thus may be useful as a sensitive and specific biomarker for clinical research.
Type: | Article |
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Title: | Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1016/j.jalz.2018.08.006 |
Publisher version: | https://doi.org/10.1016/j.jalz.2018.08.006 |
Language: | English |
Additional information: | Copyright © 2018 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
Keywords: | GAP-43, CSF biomarker, Alzheimer's disease, Differential diagnosis, Enzyme-linked immunosorbent assay |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
URI: | https://discovery.ucl.ac.uk/id/eprint/10061206 |
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