Burt, R;
Warcel, D;
Fielding, AK;
(2019)
Blinatumomab, a bispecific B-cell and T-cell engaging antibody, in the treatment of B-cell malignancies.
Human Vaccines & Immunotherapeutics
, 15
(3)
pp. 594-602.
10.1080/21645515.2018.1540828.
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Blinatumomab a bispecific B cell and T cell engaging antibody in the treatment of B cell malignancies.pdf - Accepted Version Download (1MB) | Preview |
Abstract
Blinatumomab (Blincyto, Amgen), a bi-specific antibody, is a first-in-class, targeted immunotherapy agent for treatment of B-cell malignancies with a novel mechanism of action which involves in-vivo engagement of the patient's T cells with CD19-expressing tumour cells. Clinical trials have demonstrated its efficacy in relapsed B-cell Acute Lymphoblastic Leukaemia (B-ALL) and B-cell Non-Hodgkin's Lymphoma including in patients who are refractory to chemotherapy. This review summarises the development and design of Blinatumomab, the outcome of clinical studies demonstrating its efficacy and how to manage the administration, practically, including relevant toxicities. We compare and contrast it to other emerging agents for treatment of B-cell malignancies.
| Type: | Article |
|---|---|
| Title: | Blinatumomab, a bispecific B-cell and T-cell engaging antibody, in the treatment of B-cell malignancies |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/21645515.2018.1540828 |
| Publisher version: | https://doi.org/10.1080/21645515.2018.1540828 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | B-cell non hodgkin Lymphoma, Blinatumomab, acute lymphoblastic Leukaemia, immunotherapeutics |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10060993 |
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