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Maternal age effects on fecundity and offspring egg-to-adult viability are not affected by mitochondrial haplotype

Koch, RE; Phillips, JM; Camus, MF; Dowling, DK; (2018) Maternal age effects on fecundity and offspring egg-to-adult viability are not affected by mitochondrial haplotype. Ecology and Evolution 10.1002/ece3.4516. (In press). Green open access

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Abstract

Ecology and Evolution published by John Wiley & Sons Ltd. While numerous studies have demonstrated that mitochondrial genetic variation can shape organismal phenotype, the level of contribution the mitochondrial genotype makes to life-history phenotype across the life course remains unknown. Furthermore, a clear technical bias has emerged in studies of mitochondrial effects on reproduction, with many studies conducted on males, but few on females. Here, we apply a classic prediction of the evolutionary theory of aging to the mitochondrial genome, predicting the declining force of natural selection with age will have facilitated the accumulation of mtDNA mutations that confer late-life effects on female reproductive performance. This should lead to increased levels of mitochondrial genetic variation on reproduction at later-life stages. We tested this hypothesis using thirteen strains of Drosophila melanogaster that each possessed a different mitochondrial haplotype in an otherwise standard nuclear genetic background. We measured fecundity and egg-to-adult viability of females over five different age classes ranging from early to late life and quantified the survival of females throughout this time period. We found no significant variation across mitochondrial haplotypes for the reproductive traits, and no mitochondrial effect on the slope of decline in these traits with increasing age. However, we observed that flies that died earlier in the experiment experienced steeper declines in the reproductive traits prior to death, and we also identified maternal and grandparental age effects on the measured traits. These results suggest the mitochondrial variation does not make a key contribution to shaping the reproductive performance of females.

Type: Article
Title: Maternal age effects on fecundity and offspring egg-to-adult viability are not affected by mitochondrial haplotype
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/ece3.4516
Publisher version: http://doi.org/10.1002/ece3.4516
Language: English
Additional information: Copyright © 2018 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: aging, Drosophila melanogaster, evolution of aging, mitochondrial genome, mitonuclear, mother’s curse, mtDNA, reproduction
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: http://discovery.ucl.ac.uk/id/eprint/10060953
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