Mattern, H;
Sciarra, A;
Lüsebrink, F;
Acosta-Cabronero, J;
Speck, O;
(2018)
Prospective motion correction improves high‐resolution quantitative susceptibility mapping at 7T.
Magnetic Resonance in Medicine
10.1002/mrm.27509.
(In press).
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Acosta-Cabronero_Prospective motion correction improves high-resolution quantitative susceptibility mapping at 7T_AAM.pdf - Accepted Version Download (3MB) | Preview |
Abstract
PURPOSE: Recent literature has shown the potential of high-resolution quantitative susceptibility mapping (QSM) with ultra-high field MRI for imaging the anatomy, the vasculature, and investigating their magnetostatic properties. Higher spatial resolutions, however, translate to longer scans resulting, therefore, in higher vulnerability to, and likelihood of, subject movement. We propose a gradient-recalled echo sequence with prospective motion correction (PMC) to address such limitation. METHODS: Data from 4 subjects were acquired at 7T. The effect of small and large motion on QSM with and without PMC was assessed qualitatively and quantitatively. Full brain QSM and QSM-based venograms with up to 0.33 mm isotropic voxel size were reconstructed. RESULTS: With PMC, motion artifacts in QSM and QSM-based venograms were largely eliminated, enabling-in both large- and small-amplitude motion regimes-accurate depiction of the cortex, vasculature, and other small anatomical structures that are often blurred as a result of head movement or indiscernible at lower image resolutions. Quantitative analyses demonstrated that uncorrected motion could bias regional susceptibility distributions, a trend that was greatly reduced with PMC. CONCLUSION: Qualitatively, PMC prevented image degradation because of motion artifacts, providing highly detailed QSM images and venograms. Quantitatively, PMC increased the reproducibility of susceptibility measures.
| Type: | Article |
|---|---|
| Title: | Prospective motion correction improves high‐resolution quantitative susceptibility mapping at 7T |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/mrm.27509 |
| Publisher version: | https://doi.org/10.1002/mrm.27509 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | basal ganglia, high resolution, image artifacts, ultra high field, vasculature, venography |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10060858 |
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