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Use of 3D imaging for providing insights into high-order structure of mitotic chromosomes

Yusuf, M; Kaneyoshi, K; Fukui, K; Robinson, I; (2018) Use of 3D imaging for providing insights into high-order structure of mitotic chromosomes. Chromosoma 10.1007/s00412-018-0678-5. Green open access

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Abstract

The high-order structure of metaphase chromosomes remains still under investigation, especially the 30-nm structure that is still controversial. Advanced 3D imaging has provided useful information for our understanding of this detailed structure. It is evident that new technologies together with improved sample preparations and image analyses should be adequately combined. This mini review highlights 3D imaging used for chromosome analysis so far with future imaging directions also highlighted.

Type: Article
Title: Use of 3D imaging for providing insights into high-order structure of mitotic chromosomes
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00412-018-0678-5
Publisher version: https://doi.org/10.1007/s00412-018-0678-5
Language: English
Additional information: © The Author(s) 2018. Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: Chromosome structure, Chromatin, 3D, High-resolution imaging
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > London Centre for Nanotechnology
URI: http://discovery.ucl.ac.uk/id/eprint/10060637
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