Groot, C;
Tolboom, N;
Ikonomovic, MD;
Lammertsma, AA;
Boon, BDC;
Barkhof, F;
Scheltens, P;
... van Berckel, BNM; + view all
(2018)
Quantitative PET and Histology of Brain Biopsy Reveal Lack of Selective Pittsburgh Compound-B Binding to Intracerebral Amyloidoma.
Journal of Alzheimer's Disease
, 65
(1)
pp. 71-77.
10.3233/JAD-180316.
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Barkhof_Groot - Quantitative PET and histology of brain biopsy reveal lack of selective Pittsburgh compound-B binding to intracerebral amyloidoma - accepted version.pdf - Accepted Version Download (1MB) | Preview |
Abstract
This single case study examines selective Pittsburgh compound-B (PiB) binding to an intracerebral light-chain amyloidoma using a 90-minute dynamic [11C]PiB-PET scan and brain biopsy tissue. Parametric non-displaceable binding potential (BPND) images showed low specific binding in the amyloidoma (BPND = 0.23), while relative tracer delivery was adequate (R1 = 0.44). Histology of the tissue revealed strong coloring with Congo-red, thioflavin-S, and X-34, indicating presence of amyloid. However, immunological staining with 6F/3D revealed absence of amyloid-β and histofluorescence of 6-CN-PiB, a highly fluorescent derivative of PiB, was at background levels. Our results suggest that PiB does not detect the atypical amyloid pathology associated with an intracerebral light-chain amyloidoma. These findings are of interest to clinicians and researchers applying [11C]PiB-PET to detect atypical forms of amyloid pathology.
| Type: | Article |
|---|---|
| Title: | Quantitative PET and Histology of Brain Biopsy Reveal Lack of Selective Pittsburgh Compound-B Binding to Intracerebral Amyloidoma |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3233/JAD-180316 |
| Publisher version: | https://doi.org/10.3233/JAD-180316 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, Amyloid, case study, histology, positron emission tomography, Positron-emission-tomography, Alzheimers-disease, Nervous-system, Beta, Deposits, Peptide, Images |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10060081 |
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