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Prevalence of 18F-Fluorodeoxyglucose Positron Emission Tomography Abnormalities in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy

Protonotarios, A; Wicks, E; Ashworth, M; Stephenson, E; Guttmann, O; Savvatis, K; Sekhri, N; ... Elliott, P; + view all (2018) Prevalence of 18F-Fluorodeoxyglucose Positron Emission Tomography Abnormalities in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy. International Journal of Cardiology 10.1016/j.ijcard.2018.10.083. (In press).

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Abstract

Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heritable heart muscle disease that causes sudden cardiac death in the young. Inflammatory myocardial infiltrates have been described at autopsy and on biopsy, but there are few data on the presence of myocarditis in living patients with ARVC using non-invasive imaging techniques. FDG-PET is a validated technique for detecting myocardial inflammation in clinically suspected myocarditis. We aimed to determine the prevalence of myocardial inflammation in patients with ARVC using 18F-fluorodeoxyglucose positron emission tomography (FDG-PET). Methods and results We performed a retrospective analysis of a single centre cohort of patients with ARVC referred for FDG-PET scans between 2012 and 2017 for investigation of symptoms or suspected device infection. Sixteen patients (12 male; age 42 ± 13 years) with a definite diagnosis of ARVC were identified. Seven had positive FDG-PET scans, two of whom had cardiac sarcoidosis on endomyocardial biopsy. Of the remaining five, two carried pathogenic desmoplakin mutations. FDG uptake was found in the left ventricular myocardium in all cases. One patient also had right ventricular uptake. Conclusion In this exploratory study, we show that some patients with ARVC have evidence for myocardial inflammation on FDG-PET, suggesting that myocarditis plays a role in disease pathogenesis.

Type: Article
Title: Prevalence of 18F-Fluorodeoxyglucose Positron Emission Tomography Abnormalities in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy
DOI: 10.1016/j.ijcard.2018.10.083
Publisher version: https://doi.org/10.1016/j.ijcard.2018.10.083
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Arrhythmogenic right ventricular cardiomyopathy, Cardiac magnetic resonance imaging, 18F-fluorodeoxyglucose, Positron emission tomography, Myocarditis
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Clinical Science
URI: http://discovery.ucl.ac.uk/id/eprint/10059716
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