Koutoukidis, D;
Beeken, R;
Manchanda, R;
Burnell, M;
Ziauddeen, N;
Michalopoulou, M;
Knobf, MT;
(2019)
Diet, physical activity, and health-related outcomes of endometrial cancer survivors in a behavioural lifestyle programme: the Diet and Exercise in Uterine Cancer Survivors (DEUS) parallel randomised controlled pilot trial.
International Journal of Gynecological Cancer
, 29
(3)
pp. 531-540.
10.1136/ijgc-2018-000039.
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Abstract
OBJECTIVES: To explore the effectiveness of a theory-based behavioural lifestyle intervention on health behaviours and quality of life (QoL) in endometrial cancer survivors (ECS). METHODS/MATERIALS: This was a secondary analysis of a randomised controlled pilot trial conducted in two UK hospitals enrolling disease-free stage I-IVA ECS. Participants were allocated to an 8-week group-based healthy eating and physical activity intervention or usual care (UC) using 1:1 minimisation. Participants were followed up at 8- and 24-weeks, with the 8-week assessment being blinded. Diet, physical activity, and QoL were measured with the Alternative Healthy Eating Index 2010 (AHEI-2010), Stanford 7-Day Physical Activity Recall, and the EORTC-QLQ-C30, respectively. We analysed all eligible participants using the intention-to-treat approach in complete cases, adjusting for baseline values, body mass index, and age. RESULTS: We enrolled 60 of the 296 potentially eligible ECS (May - December 2015). Fifty-four eligible participants were randomised to the intervention (n=29) or UC (n=31), and 49 had complete follow-up data (n=24 in the intervention and n= 25 in UC). Intervention adherence was 77%. At 8-weeks, participants in the intervention improved their diet compared to UC (difference in AHEI-2010 score 7.5 (95% CI: 0.1, 14.9), p=0.046) but not their physical activity (0.1 MET-h/day 95% CI: (-1.6, 1.8), p=0.879), or global QoL score (5.0 (95% CI: -3.4, 13.3), p=0.236). Global QoL improved in intervention participants at 24-weeks (difference 8.9 (95% CI: 0.9, 16.8), p=0.029). No intervention-related adverse events were reported. CONCLUSIONS: The potential effectiveness of the intervention appeared promising. A future fully-powered study is needed to confirm these findings.
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