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Medical management and antiepileptic drugs in hypothalamic hamartoma

Cross, JH; Spoudeas, H; (2017) Medical management and antiepileptic drugs in hypothalamic hamartoma. Epilepsia , 58 (S2) pp. 16-21. 10.1111/epi.13758. Green open access

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Abstract

Hypothalamic hamartoma may present with epilepsy, specifically gelastic or dacrystic seizures, or endocrine dysfunction, commonly precocious puberty. The epilepsy in many patients is drug resistant, and has a high association with progressive cognitive, learning and behavioral difficulty. Medical treatment of seizures remains problematic, with many resistant to drug treatment. Surgical resection, or disconnection of the hamartoma provides the optimal chance of seizure control but with a relatively high risk of endocrine dysfunction, the result of interference with the hypothalamic‐pituitary axis in many. Careful assessment and monitoring by specialist centers with discussion of optimal intervention is required for individual cases.

Type: Article
Title: Medical management and antiepileptic drugs in hypothalamic hamartoma
Event: 2nd International Hypothalmic Hamartomas Symposium
Location: Marseille, FRANCE
Dates: September 2013
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/epi.13758
Publisher version: https://doi.org/10.1111/epi.13758
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Hypothalamic hamartoma, Epilepsy, Gelastic seizures, Antiepileptic drugs, Ketogenic diet
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Developmental Neurosciences Prog
URI: http://discovery.ucl.ac.uk/id/eprint/10059086
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