Chen, Y; Guan, H; Hagen, CK; Olivo, A; Anastasio, MA; (2017) Single-shot edge illumination x-ray phase-contrast tomography enabled by joint image reconstruction. Optics Letters , 42 (3) pp. 619-622. 10.1364/OL.42.000619.

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Abstract

Edge illumination x-ray phase-contrast tomography (EIXPCT) is an emerging x-ray phase-contrast tomography technique for reconstructing the complex-valued x-ray refractive index distribution of an object. Conventional image reconstruction approaches for EIXPCT require multiple images to be acquired at each tomographic view angle. This contributes to prolonged data-acquisition times and elevated radiation doses, which can hinder in vivo applications. In this work, a new “single-shot” method is proposed for joint reconstruction (JR) of the real and imaginaryvalued components of the refractive index distribution from a tomographic data set that contains only a single image acquired at each view angle. The proposed method is predicated on a nonlinear formulation of the inverse problem that is solved by using a gradient-based optimization method. The method is validated and investigated using computersimulated and experimental EIXPCT data sets.

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