Ousdal, OT;
Milde, AM;
Craven, AR;
Ersland, L;
Endestad, T;
Melinder, A;
Huys, QJ;
(2019)
Prefrontal Glutamate Levels Predict Altered Amygdala-prefrontal Connectivity in Traumatized Youths.
Psychological Medicine
, 49
(11)
pp. 1822-1830.
10.1017/S0033291718002519.
Preview |
Text
prefrontal_glutamate_levels_predict_altered_amygdalaprefrontal_connectivity_in_traumatized_youths.pdf - Published Version Download (413kB) | Preview |
Abstract
BACKGROUND:Neurobiological models of stress and stress-related mental illness, including post-traumatic stress disorder, converge on the amygdala and the prefrontal cortex (PFC). While a surge of research has reported altered structural and functional connectivity between amygdala and the medial PFC following severe stress, few have addressed the underlying neurochemistry.METHODS: We combined resting-state functional magnetic resonance imaging measures of amygdala connectivity with in vivo MR-spectroscopy (1H-MRS) measurements of glutamate in 26 survivors from the 2011 Norwegian terror attack and 34 control subjects.RESULTS: Traumatized youths showed altered amygdala-anterior midcingulate cortex (aMCC) and amygdala-ventromedial prefrontal cortex (vmPFC) connectivity. Moreover, the trauma survivors exhibited reduced levels of glutamate in the vmPFC which fits with the previous findings of reduced levels of Glx (glutamate + glutamine) in the aMCC (Ousdal et al.2017) and together suggest long-term impact of a traumatic experience on glutamatergic pathways. Importantly, local glutamatergic metabolite levels predicted the individual amygdala-aMCC and amygdala-vmPFC functional connectivity, and also mediated the observed group difference in amygdala-aMCC connectivity.CONCLUSIONS: Our findings suggest that traumatic stress may influence amygdala-prefrontal neuronal connectivity through an effect on prefrontal glutamate and its compounds. Understanding the neurochemical underpinning of altered amygdala connectivity after trauma may ultimately lead to the discovery of new pharmacological agents which can prevent or treat stress-related mental illness.
| Type: | Article |
|---|---|
| Title: | Prefrontal Glutamate Levels Predict Altered Amygdala-prefrontal Connectivity in Traumatized Youths |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1017/S0033291718002519 |
| Publisher version: | https://doi.org/10.1017/S0033291718002519 |
| Language: | English |
| Additional information: | This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Amygdala, functional MRI, glutamate, prefrontal cortex, PTSD, stress |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10058736 |
Archive Staff Only
 |
View Item |
